Sanitized copy Approved for Release 2011/09/14 : CIA-RDP80-00809A000600380033-3
CLASSIFICATION CONFIDENTIAL
CENTRAL ‘INTELLIGENCE AGENCY
INFORMATION FROM
FOREIGN DOCUMENTS OR RADIO BROADCASTS
COUNTRY USSR
SUBJECT Scientific – Medicine
HOW PUBLISHED Monthly periodical
WHERE PUBLISHED leningrad
DATE Oct 1950
PUBLISHED
LANGUAGE Russian
SOURCE
DATE OF INFORMATION 1950
DATE DIST. ac Feb 1951
NO. OF PAGES 2
THIS IS UNEVALUATED INFORMATION
SOURCE Prlroda, VoI No 10, pp 22-27.
BIOCHEMICAL RESEMBLANCE BETWEEN ENDOPARASITES AND MALIGNANT TUMORS
Pror.V. V. Alpatov
Endoparasites and malignant cancer tumors resemble each other In many respects by reason of similar conditions under which they grow and exist. This suggested long ago the idea In regard to the parasitic nature of cancer tumors.
Parasitic worms which live the Intestines exhibit a pronounced anaerobic metabolism They deposit In their bodies large quantities of glycogen. The accumulation of glycogen is one of the properties which they share with cancer tumors. The tissues of both intestinal parasitic worms and cancer tumors belong to the amphibiotic euryoxybiotical-aerofermentor type (Th. Brands terminology), I.e., they are a
characterized a metabolism involving incomplete oxidations under aerobic conditions and are at the same time adapted to aerobic conditions. (2)
In 1938, H. Mauss synthesized the alkylated amnio xanthone Myracyl D, which was found to be effective both against Bilharzia and malignant cancer tumors (3). The guanine analog Guanozoio (5-amino-7-hydroxy -1 – v – triazolo pyrimidine synthesized by G. Kidder (4) suppress the synthesis of nucleic acids (or, to be more precise, purine derivatives) In Infusorla which are unable to convert adenine into guanine as well as in malignant cancer tumors of mice. It is interesting that Guanozolo is an optically active compound having dextrarotatory activity.
In Investigating the relative toxic effect of atebrln on enanthiomorphs on various animals, the author of this article, together O. K. Nastyukova (2) found that the majority of animals are more sensitive to levarotatory atebrln . However, the following test objects proved to be more sensitlve to dextrarotatory atebrin: Erlick’s adenocarcinoma (a gland cancer of mice), species of mollusks the body of which is turned In a left-handed spiral, and nematodes which live as parasites In the Intestine of frogs. Thus tissues of
malignant cancer tumors and parasitic worms are distinguished from healthy tissue and from that
of non-parasitic worms by an opposite reaction to optical enanthiomorphs atebrin.
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roved for Release 2011/09/14 : CIAZRDP80-00809A0006
Sanitized copy Approved for Release 2011/09/14 : CIA-RDP80-00809A000600380033-3
CLASSIFICATION CONFIDENTIAL
There are reasons to believe that the specific biological characteristics of malignant cancer tumors tissue and parasites comprise the following elements: (1) presence of specific antigens in both malignant tissue and parasites; (2) optical inversion of the receptors of certain optically active compounds such as atebrin; and (3) peculiarities of purine metabolism in malignant tissue which .: are connected with the synthesis of nucleic acids, and subsequently, of nucleoproteins that are important constituents of cell nuclei. One may assume that malignancy is closely connected with alterations .of the chemical properties of protoplasm, specific properties of enzymes, and possibly peculiarities of the protein carriers of enzymes.
Under the circumstances, recent work on proteins of malignant cancer tumors which is being carried out in the USSR (5, 6, 7) assumes particular importance.
BIBLIOGRAPHY
1, V. V. Alpatov anu O. K. Nastyukova, DAN SSSR, Vol LIX, No 6, 1948.
2. V. V. Alpatov and O. K. Nastyukova, Byulleten’ Moskovakogo Obshchestva
Ispytaniya Prirody, No 6, 1947
3. O, Hackmann, R. Goennert, and H. Mauss, Naturwissenschaften, No 1, 29, 1949.
4. G. Kidder, et al, Nature, Wol CIX, p 511, 20/Ma9, 1949
5. B. I. Zbarskiy, Vrachebnoye Delo, No 2-3, 1947.
6. I. B. Zbarskiy, Uspekhi Sovremennoy Biologii,
7. V. Orekhovich, Biokhimiya, No 5, 1940
